Moisture In Pharmaceutical Powders

It is important that moisture levels are accurately maintained throughout the wet granulation or drying process within the fluid dryer.? This ensures consistent product formation in the tableting and pelletizing processes, which follow and ensure the effectiveness of the drug.? Continual monitoring and control of moisture will increase productivity and maximize the efficiency of the operation.

Pharmaceutical Manufacturing Processes

Granulation Process: A water based solution is slowly sprayed onto the excipients to ensure even distribution.? Air is simultaneously pumped through the bed of powder to gently lift and mix the ingredients.

Drying Process: This commences after the aqueous solution has been added (when preceded by a granulation operation).? When the batch reaches the desired moisture content, the air shuts off and the bowl of powder is transferred to the next operation.

Measurement and Location

Traditionally, moisture content is approximated by measuring the temperature of the exiting air.? This can prove unreliable as it is dependent upon the relative humidity and temperature of the incoming air.? To further confirm that the moisture has reached the required level, a sample is removed for laboratory testing.

Using the MCT 360? NIR on-lin moisture analyzer, moisture can be measured instantaneously “in situ” by using either a sappire viewing window, or a probe with an air purge to ensure non-adherence of product to the window.? Alternatively, if there are multiple flid bed dryers, an MCT600 laboratory instrument can be set up on a cart and transported to each Dryer in order to obtain instantaneous readings on samples extracted from the bowl.

INTRODUCING THE PTLST PORTABLE THERMOMETER SERIES

PORTABLE IR THERMOMETER COMBINES LASER AND TELESCOPIC SIGHTING FOR SMALL TARGET, LONG DISTANCE, PRECISION AIMING

Twin lasers and a built-in optical telescope simplify precise aiming on small targets at extended distances with Process Sensor Corp.?s latest addition to their range of portable infrared thermometers.? The Models PSC PTLST-20-1M and 2M also feature a dual grip handle to assist steady aiming.

Typical applications for the portable instrument are slag free molten metals and crucibles, furnace surveys in the steel, glass and refractory industries, molten glass, semiconductor wafers, composites, ceramics, induction heating of metals and spot measurements in vacuum furnaces.

Two models offer temperature ranges of 650 to 1800?C on the 1M version, or 385 to 1600?C on the 2M.? Spectral responses of 1.0?m and 1.6?m respectively, enhance measurement accuracy when monitoring relatively low or variable emissivity targets.? The two lasers are mounted such that the beams converge at the target distance, illuminating the measured area.? A Ni-MH rechargeable battery provides a generous 25 hours of operation without the lasers, and 5 hours with the lasers and display back-lighting on.

Other outstanding features include an internal 2000 reading data logger, and max/min audible, and visual three color alarm signaling on the integral display.? A USB interface and included PSC Connect software are provided for downloading data to a computer for storage and analysis.

For more information, please visit our website at www.processsensorsir.com

NEW IR SENSOR INTRODUCTION

COMPACT, SELF CONTAINED, 2 WIRE IR THERMOMETER PACKS POWERFUL FEATURES IN A SMALL SPACE

Digital electronics and precision engineering contribute to the small size of the latest addition to Process Sensor Corps.? IR thermometer line.

The DS-40N or DG-40N series of stainless steel pyrometers are 124.5mm long overall by M40x1.5 threaded diameter, operates in a loop powered mode to produce a linear 4 to 20mA output, over selected temperature ranges from an overall span of 250 to 2500?C in two models.? In a 4 wire mode, the sensor also offers green LED, illuminating the exact target size, or laser aiming.

Depending on the model, either DS-40N or DG-40N, and temperature range, selected optics provide small target, close focus e.g. 1.2mm diameter at 210mm distance, or extended focus out to 4m with a 20mm diameter target.? A USB connection gives access to PC adjustments of such parameters as emissivity, response time, temperature sub-range and peak picker, with supplied software.

Without cooling, the non-contact temperature sensor will operate in ambient temperatures up to 70?C, and in higher ambient of 200?C with the optional cooling and lens-purging jacket.? The Model DS-40N has a spectral response of 0.8 to 1.1?m, and the DG-40N 1.5?m to 1.8?m, for minimum vulnerability to variable target emissivity, and to optimize the effective emissivity of low radiance targets.

The temperature ranges, optics, rugged construction and signal processing capability will appeal to users in the Steel, Ceramics and Glass Industries, Cement and Refractory manufacture, Induction Heating and Sintering operations.

Process Sensors? ?PSC Spot Software? supports sensor set-up, multi-tasking, graphic display of temperature trends, and data logging, and in general allows the user to customize the sensor to the application.

Detailed specification information can be found at www.processsensorsIR.com

NEW IR SENSOR INTRODUCTION

PSC-SSS laser small

IR THERMOMETER INCORPORATES TWIN LASER IDENTIFICATION OF TARGET SPOT LOCATION AT ANY DISTANCE

With an overall size of only 4? (100mm) long x 2.2? (55mm) dia, Process Sensors? latest addition to their family of compact, non-contact, on-line temperature sensors features dual, converging lasers that brightly illuminate the exact location of the target spot at any distance from the lens.? This feature greatly simplifies sensor aiming, and eliminates ambiguity that could result in error readings.

The Model PSC-SSS-Laser-3M offers a wide overall temperature span of 50 to 600?C, a short wavelength, spectral response of 2.3?m, and selectable target spot sizes from 1.75mm at 70mm distance, 90mm at 3600mm, 0.7mm at 70mm or 36mm at 3600mm, depending on the selection of optics and model.? The specification particularly suits the thermometer to secondary metal processing, and the measurement of oxides and ceramic materials.

Signal processing and programming electronics are contained in a rugged 2.75? X 3.5? (70 x 89mm) housing that can be mounted up to 9.8 feet (3m) from the sensor as standard, or optionally 26 feet (8m) or 49 feet (15m), providing greater immunity from electromagnetic interference, mechanical shock, and high ambient temperatures.? The sensing head is able to withstand ambient temperatures of up to 85?C without cooling.

Functions provided by the signal processing and programming unit include: analog outputs of 0/4-20mA, 0-5/10V, and J and K thermocouple.? Optional digital outputs are: USB, RS 232, RS 485, Profibus DP and Ethernet.? Programmable parameters include emissivity and transmissivity adjustments, peak and valley hold, averaging, and extended hold with threshold and hysteresis.

Process Sensors? ?PSC Spot Software? supports sensor set-up, multi-tasking, graphic display of temperature trends, and data logging, and in general allows the user to customize the sensor to the application.? More information can be found at www.processsensorsIR.com

Process Sensors Corp. is a private company with manufacturing facilities located in Milford, MA.? The company manufactures temperature and moisture instruments, and associated calibration systems.? Technical and application support is provided throughout the USA, Great Britain and Eastern Europe.